СКАРСЕЛЛИ Мария (IT),ПИЦЦА Марияграция (IT),ЛЕУЦЦИ Розанна (IT),АРИКО Мария (IT),МАРТИНЕЛЛИ Мануэле (IT),ДАУС Джиллиан (GB)
申请号：
RU2014127714
公开号：
RU2014127714A
申请日:
2012.12.07
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. An immunogenic composition comprising a combination of Clostridium difficile antigens, said combination comprising: (a) ToxB-GT antigen and TcdA antigen； or (b) ToxA-GT antigen and TcdB.2 antigen. The immunogenic composition of claim 1, wherein the ToxB-GT antigen and / or the ToxA-GT antigen are detoxified. The immunogenic composition according to claim 1 or 2, wherein: the ToxB-GT antigen is a polypeptide that contains or consists of the amino acid sequence: (a) having 80% or more identity with the sequence of SEQ ID NO: 18 or SEQ ID NO: 60, and / or (b) which is a fragment of at least 7 consecutive amino acids of SEQ ID NO: 18 or SEQ ID NO: 60, or a polypeptide having 80% or more identity with the sequence of SEQ ID NO: 18 or SEQ ID NO: 60, and which contains the epitope of SEQ ID NO: 18 or SEQ ID NO: 60； the ToxA-GT antigen is a polypeptide that contains live or consist of the amino acid sequence: (a) having 80% or more identity with the sequence of SEQ ID NO: 4 or SEQ ID NO: 56, and / or (b) which is a fragment of at least 7 consecutive amino acids of SEQ ID NO : 4 or SEQ ID NO: 56, or a polypeptide having 80% or more identity with the sequence of SEQ ID NO: 4 or SEQ ID NO: 56, and which contains the epitope of SEQ ID NO: 4 or SEQ ID NO: 56； TcdA antigen is a polypeptide that contains or consists of an amino acid sequence: (a) having 80% or more identity with by SEQ ID NO: 1, and / or (b) which is a fragment of at least 7 consecutive amino acids of SEQ ID NO: 1, or a polypeptide having 80% or more identity with the sequence of SEQ ID NO: 1, and which contains epitope of SEQ ID NO: 1； TcdB antigen is1. Иммуногенная композиция, содержащая комбинацию антигенов Clostridium difficile, причем указанная комбинация содержит:(а) антиген ToxB-GT и антиген TcdA； или(b) антиген ToxA-GT и антиген TcdB.2. Иммуногенная композиция по п. 1, где антиген ToxB-GT и/или антиген ToxA-GT являются детоксицированными.3. Иммуногенная композиция по п. 1 или 2, где:антиген ToxB-GT пред
