Anton IGONIN,Paul HERSCU,Natalya LAZAREVA,Valentin URAROV
申请号：
US14436062
公开号：
US20160058850A1
申请日:
2013.11.13
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention is based, in part, on our analysis of C1-INH levels in various patient populations. Accordingly, in a first aspect, the invention features methods for assessing the protective capacity of endogenous C1-INH in a patient who has been diagnosed with ARDS, sepsis or a sepsis-related condition, a burn or a burn-related condition, SJS, CABG-related states and/or other traumatic injuries. The methods can include the steps of: (a) providing a fluid sample from the patient； (b) determining the amount of C1-INH functional activity in the sample； and (c) comparing the amount of C1-INH functional activity to a reference standard. Where the level of C1-INH functional activity is comparable to that within a healthy patient population, the patient's own protective capacity is compromised.
