The present invention relates to particles of polysaccharide encapsulated with one or more growth factors, which comprises one or more growth factors and a polysaccharide shell, wherein the polysaccharide shell forms a space to encapsulate the growth factor by electrostatic interaction. In addition, the present invention further relates to a method for manufacturing particles of polysaccharide encapsulated with growth factor, which comprises the following steps: (A) providing a polysaccharide solution and one or more growth factors, wherein the pH value of the polysaccharide solution is about pH 4.6-6； and (B) adding the growth factor to the polysaccharide solution, and adjusting the pH value of the polysaccharide solution to about pH 6-8, in order to obtain the particles of polysaccharide encapsulated with growth factor. According to the polysaccharide shell structure, the growth factor can be stored for a long period and heal the skin wound, mucositis, and corneal ulcer effectively.本發明係有關於一種包覆生長因子之多醣體微粒子，包括：一或多種生長因子；以及一多醣體殼層。其中多醣體殼層係形成一空間，以包覆生長因子，且多醣體殼層係透過靜電作用包覆生長因子。此外，本發明亦關於一種包覆生長因子之多醣體微粒子之製備方法，包括下列步驟：(A)提供一多醣體溶液以及包含一或多種生長因子，其中多醣體溶液之酸鹼值係界於pH 4.6-6間；以及(B)加入生長因子至多醣體溶液，並調整多醣體溶液之酸鹼值至pH 6-8間，以得到包覆生長因子之多醣體微粒子。本發明包覆生長因子之多醣體微粒子具有長期保存及治療皮膚傷口、粘膜潰瘍、及角膜修復之功效。
