Centre National de la Recherche Scientifique (CNRS);lnstitut National de Ia Sante et de Ia Recherche Medicale (INSERM);Universite Paris Descartes;Novo Nordisk A/S
The present invention provides an in vitromethod for obtaining cells of the pancreatic endocrine lineage, comprising a step of culturing pancreatic progenitor cells, wherein said pancreatic progenitor cells are in a cell culture medium comprising at least one BET inhibitor.