Bernard Thorens,Carine Poussin,Diana Hall,MARIA JIMENEZ
申请号：
BRPI0921274
公开号：
BRPI0921274A2
申请日:
2009.11.05
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
The present invention concerns Plac8, a new target involved in adipogenesis modulation. Using a siRNA approach, the inventors demonstrated that decrease in Plac8 activity in preadipocytes and adipose tissue induces a decrease in adipogenesis. Thus, the present invention relates to modulators of Plac8 activity as well as screening test for identification of modulators of the activity of this target, and their use, especially in pharmaceutical composition, to modulate adipogenesis and thus treat obesity and related disorders.
