AHMED, SALAH U.,ZU, YANMING,LEPREE, JASON,PRAJAPTI, HETALBEN,CHOWDHURY, TAHSEEN A.
申请号：
CA3014032
公开号：
CA3014032A1
申请日:
2016.10.24
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The invention relates to extended-release formulations comprising: (i) a poorly water-soluble active pharmaceutical ingredient； and (ii) a non-aqueous liquid vehicle comprising (a) a hydrophobic lipid comprising a glyceryl ester of a C6 - C24 fatty acid, or (b) a hydrophilic organic compound selected from the group consisting of polyethylene glycol, propylene glycol, glycerin, and dimethylsulfoxide, or (c) a combination of (a) and (b), and (iii) an amphiphilic agent wherein the active pharmaceutical ingredient is dispersed as discrete particles having a D90 particle size of about 0.5 µm to about 25 µm in the formulation, and wherein the formulation is non-gelling and thixotropic with a viscosity of less than 10 poise at a shear rate of 10/s at 25°C.
