For safe storage and simple and reliable removal of tablets T by a user, a medicament dispenser 1 is created that has receiving means for an exchangeable cartridge 900 containing the medicament portions. The medicament dispenser 1 is equipped with at least one locking means for locking the cartridge 900 and with at least one means for cancelling the locking of the cartridge 900 in the medicament dispenser 1. The at least one locking means is movable in rotation.