The present disclosure relates to a cannabinoid based dry or aqueous self-emulsificationsystem for infusing a composition with a cannabinoid. The self-emulsificationsystemcomprises: a) at least one cannabinoid in a carrier oil; b) a plurality ofself-emulsifiers having atargeted combined HLB value; and c) a targeted plurality of self-emulsifiersto oil ratio;wherein b) and c) operate to solubilize at least 1 mg of the cannabinoid in 1mL of thecomposition. The dry self-emulsification system is in the form of a self-emulsifiable solidwhich spontaneously forms an emulsion after the addition of an aqueous medium,whereas thecomposition spontaneously forms an emulsion upon dilution of the aqueous self-emulsificationsystem with water. Methods of making and using such self-emulsificationsystems, andcannabinoid concentrate compositions and cannabis infused compositionscomprising suchself-emulsification systems to form beverages, human and pet edibles andconfectionaries arealso encompassed by the present disclosure.