The invention relates to substituted pyridine compounds of Formula I:and the pharmaceutically acceptable salts and solvates thereof, wherein R1a, A1, A2, E, Z1, and Z2 are defined as set forth in the specification. G is G-4.The invention is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of sodium channels. Compounds of the present invention are especially useful for treating pain.