Emory University;Children's Healthcare of Atlanta, Inc.
发明人:
Jacques Galipeau,Spencer Ng
申请号：
US15735158
公开号：
US20180155439A1
申请日:
2016.06.08
申请国别(地区):
US
年份:
2018
代理人:
摘要：
This disclosure relates to compositions and conjugates comprising an interleukin, e.g., IL-15 and a polypeptide that specifically binds TGF-beta. Typically the polypeptide that specifically binds TGF-beta is a type II TGF-beta receptor. In certain embodiments, the type II TGF-beta receptor is a human isoform, fragment or variant thereof. Uses for treating or preventing cancer and infectious diseases are contemplated.
