MANOHARAN, MUTHIAH,RAJEEV, KALLANTHOTTATHIL G.,NARAYANANNAIR, JAYAPRAKASH K.,MAIER, MARTIN
申请号：
CA2708153
公开号：
CA2708153C
申请日:
2008.12.04
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present invention provides iRNA agents comprising at least one subunit ofthe formula (I): wherein: A andB are each independently for each occurrence O, N(R N) or S； X and Y are eachindependently for each occurrence H, OH, a hydroxylprotecting group, a phosphate group, a phosphodiester group, an activatedphosphate group, an activated phosphite group,a phosphoramidite, a solid support, -P(Z')(Z")0- nucleoside, -P(Z')(Z")O-oligonucleotide, a lipid, a PEG, a steroid, a lipophile, apolymer, -P(Z')(Z")O-Linker-OP(Z"')(Z")O-oligonucleotide, a nucleotide, anoligonucleotide, - P(Z')(Z")-formula(I), -P(Z')(Z")-or -Linker-R； R is L G, -Linker-L G, or has the structure shown below: L G isindependently for each occurrence a carbohydrate, e.g.,monosaccharide, disaccharide, trisaccharide, tetrasaccharide, oligosaccharide,polysaccharide； R N is independently for each occur-remce H, methyl, ethyl, propyl, isopropyl,butyl, or benzyl； and Z', Z", Z"'and Z are each independently for each occurrence O orS.
