MINOMI, Kenjiro,TANAKA, Yasunobu,FEINSTEIN, Elena,AVKIN-NAHUM, Sharon,KALINSKi, Hagar,METT, Igor,PAYNE, Joseph E.,KNOPOV, Victor,WITTE, Richard P.,YING, Wenbin,LIU, Yun,PERELMAN, Loren A.,AKOPIAN, Vio
申请号：
DK12730301
公开号：
DK2717921T3
申请日:
2012.06.08
申请国别(地区):
DK
年份:
2016
代理人:
摘要：
What is described are pharmaceutical compositions comprising a double-stranded nuclei acid molecule comprising a sense strand and an antisense strand wherein the sense and antisense strands are selected from the oligonucleotides described as SERPINH1_2 (SEQ ID NOS: 60 and 127), SERPTNH1-45a (SEQ ID NOS: 98 and 165), and SERPTNH1_51 (SEQ ID NOS: 101 and 168), and drug carrier comprising a mixture of a retinoid and a lipid vesicle, and methods of using these pharmaceutical compositions to treat a disease associated with hsp47 expression, including fibrosis.
