Daniel A. Portnoy;Anat A. Herskovits;Gregory Crimmins
发明人:
Daniel A. Portnoy,Anat A. Herskovits,Gregory Crimmins
申请号：
US12514787
公开号：
US08277797B2
申请日:
2007.11.21
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Mutant Listeria bacteria that modulate interferon-β production are provided. The subject bacteria are characterized by having a mutation in a gene chosen from a TetR gene, a LadR gene, a VirR gene, a MarR gene a MdrL gene, a MdrT gene and a MdrM gene. The subject bacteria find use in a variety of applications, where representative applications of interest include, but are not limited to: (a) use of the subject bacteria as adjuvants； (b) use of the subject bacteria as delivery vectors for introducing macromolecules into a cell； (c) use of the subject bacteria as vaccines for eliciting or boosting a cellular immune response； etc.
