The present specification provides compositions comprising a thioxanthone-based autophagy inhibitor and/or a cancer therapeutic autophagy inducing compound, pharmaceutical kits comprising these compositions, and methods of treating cancer using such compounds, compositions and kits. Additionally, the present specification provides methods of treating cancer using a thioxanthone-based autophagy inhibitor and a radiotherapy.本說明書提供包含基於硫酮之自體吞噬抑制劑及/或誘發自體吞噬之癌症治療性化合物的組成物、包含此等組成物之醫藥套組及使用該等化合物、組成物及套組治療癌症之方法。另外,本說明書提供使用基於硫酮之自體吞噬抑制劑及放射線療法治療癌症之方法。