GAUDET, FRANCOIS,ATTAR, RICARDO,HARMAN, BENJAMIN C.,LI, YINGZHE,LUO, JINQUAN,MCDAID, RONAN,POMERANTZ, STEVEN C.,TAM, SUSAN H.,TEPLYAKOV, ALEXEY,WHEELER, JOHN,WU, SHENG-JIUN,NEMETH, JENNIFER F.
申请号：
PL15766973
公开号：
PL3189081T3
申请日:
2015.09.03
申请国别(地区):
PL
年份:
2020
代理人:
摘要：
Provided herein are antibodies that immunospecifically bind to CD123. Also described are related polynucleotides capable of encoding the provided CD 123-specific antibodies or antigen-binding fragments, cells expressing the provided antibodies or antigen-binding fragments, as well as associated vectors and detectably labeled antibodies or antigen-binding fragments. In addition, methods of using the provided antibodies are described. For example, the provided antibodies may be used to diagnose, treat, or monitor CD123-expressing cancer progression, regression, or stability； to determine whether or not a patient should be treated for cancer； or to determine whether or not a subject is afflicted with CD123-expressing cancer and thus may be amenable to treatment with a CD123-specific anti-cancer therapeutic, such as the multispecific antibodies against CD123 and CD3 described herein.
