An end effector assembly (1000) for use with a surgical instrument is disclosed. The end effector assembly comprises a first jaw (1010) defining a channel (1011) therein, a second jaw, and a threaded rod (1030) extending within the channel. The end effector assembly further comprises a replaceable staple cartridge (1020) comprising a sled (1050), wherein the replaceable staple cartridge is configured to be seated in the channel, and a firing member (1040) operably engaged with the threaded rod, wherein the sled and the firing member are configured to move from a proximal position toward a distal position when the threaded rod is rotated in a first direction.
