GERDES, CHRISTIAN,KLEIN, CHRISTIAN,NICOLINI, VALERIA G.,UMANA, PABLO
申请号:
HK15111524.5
公开号:
HK1210789A
申请日:
2015.11.23
申请国别(地区):
HK
年份:
2016
代理人:
摘要:
The present invention provides combinations of (a) an immunoconjugate comprising a first antibody engineered to have reduced effector function and an effector moiety, and (b) a second antibody engineered to have increased effector function, for use in treating a disease in an individual in need thereof. Further provided are pharmaceutical compositions comprising the combinations, and methods of using them.