To maintain physical fitness and health of middle-agedand older persons living in the threshold of the aging society,the present invention provides a fatigue reducing agent whichis highly effective for preventing and reducing fatigue,wherein the agent is made of a composition of substances thatare very safe so that long-term administration is possible.A composition containing reduced coenzyme Q was found to beeffective for preventing and reducing fatigue, includingmuscle fatigue. Since the fatigue reducing effect of thecomposition of the present invention is seen not only in youngrats but also more pronounced in aged rats, the presentinvention can provide the fatigue reducing agent which is veryuseful, especially, for middle-aged and older persons as wellas for young people.
