A device and method for delivery of a therapeutic substance to the body of a patient having an infusion catheter configured to be inserted into a tissue of a patient, wherein a volume surrounding the insertion site comprises an infused region a catheter securing element configured to be adhered to the skin of the patient and further configured to secure the infusion catheter to the skin a treatment element configured to apply a treatment to the vicinity of the infused region to modify the pharmacokinetic and/or pharmacodynamic profile of the substance.
