WISSNER, ALLAN,REICH, MARVIN FRED,JOHNSON, BERNARD DEAN,JR. FLOYD, MIDDLETON BRAWNER,KITCHEN, DOUGLAS B.,TSOU, HWEI-RU
申请号：
HU0002112
公开号：
HU229549B1
申请日:
1998.04.02
申请国别(地区):
HU
年份:
2014
代理人:
摘要：
This invention provides compounds having formula (1), wherein: X is cycloalkyl which may be optionally substituted； or is a pyridinyl, pyrimidinyl, or phenyl ring； wherein the pyridinyl, pyrimidinyl, or phenyl ring may be optionally substituted； n is 0-1； Y is -NH-, -O-, -S-, or -NR-； R is alkyl of 1-6 carbon atoms； R1, R2, R3 and R4 are each, independently, hydrogen, halogen, alkyl, alkenyl, alkynyl, alkenyloxy, alkynyloxy, hydroxymethyl, halomethyl, alkanoyloxy, alkenoyloxy, alkynoyloxy, alkanoyloxymethyl, alkenoyloxymethyl, alkynoyloxymethyl, alkoxymethyl, alkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl, alkylsulfonamido, alkenylsulfonamido, alkynylsulfonamido, hydroxy, trifluoromethyl, cyano, nitro, carboxy, carboalkoxy, carboalkyl, phenoxy, phenyl, thiophenoxy, benzyl, amino, hydroxyamino, alkoxyamino, alkylamino, dialkylamino, aminoalkyl, N-alkylaminoalkyl, N,N-dialkylaminoalkyl, phenylamino, benzylamino, formulae (a, b, c, d, e, f, g, h, i, j, k, l, m, n, o, p, q or r)； R5 is alkyl which may be optionally substituted, or phenyl which may be optionally substituted； R6 is hydrogen, alkyl, or alkenyl； R7 is chloro or bromo； R8 is hydrogen, alkyl, aminoalkyl, N-alkylaminoalkyl, N,N-dialkylaminoalkyl, N-cycloalkylaminoalkyl, N-cycloalkyl-N-alkylaminoalkyl, N,N-dicycloalkylaminoalkyl, morpholino-N-alkyl, piperidino-N-alkyl, N-alkyl-piperidino-N-alkyl, azacycloalkyl-N-alkyl, hydroxyalkyl, alkoxyalkyl, carboxy, carboalkoxy, phenyl, carboalkyl +, chloro, fluoro, or bromo； Z is amino, hydroxy, alkoxy, alkylamino, dialkylamino, morpholino, piperazino, N-alkylpiperazino, or pyrrolidino； m = 1-4, q = 1-3, and p = 0-3； any of the substituents R1, R2, R3 or R4 that are located on contiguous carbon atoms can together be the divalent radical -O-C(R8)2-O-； or a pharmaceutically acceptable salt thereof with the proviso that when Y is -NH-, R1, R2, R3 and R4 are hydrogen, and n is O, X is not 2-methylphenyl, which are inhibitors of protein tyrosine kinase.
