Provided are methods, assays, and kits for detecting hepatocellular carcinoma, as well as methods for stratifying subjects among higher and lower risk categories for having hepatocellular carcinoma, and methods of treating and managing treatment of subjects that are suspected or at risk of having hepatocellular carcinoma. Although previous work has attempted to address the need for a highly sensitive, early predictor of hepatocellular carcinoma by assessment of one or more biological factors, none have approached the degree of sensitivity that is required for clinically relevant determination of whether a subject, especially a non-symptomatic subject, has that condition. The present inventors have discovered that certain combinations of factors fulfill this need by conferring a high level of accuracy that was not previously attainable.Se proporcionan metodos, ensayos y kits para detectar carcinoma hepatocelular, asi como metodos para estratificar sujetos entre categorias de riesgo mas altas y mas bajas por tener carcinoma hepatocelular y metodos para tratar y manejar el tratamiento de sujetos que se sospecha o estan en riesgo de tener carcinoma hepatocelular； aunque el trabajo anterior ha intentado abordar la necesidad de un indicador temprano altamente sensible de carcinoma hepatocelular mediante la evaluacion de uno o mas factores biologicos, ninguno se ha acercado al grado de sensibilidad que se requiere para la determinacion clinicamente relevante de si un sujeto, especialmente un sujeto no sintomatico, tiene esa condicion； los inventores de la presente han descubierto que ciertas combinaciones de factores satisfacen esta necesidad al conferir un alto nivel de exactitud que no era alcanzable previamente.
