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PARTICULATE HYALURONIC ACID FORMULATIONS FOR CELLULAR DELIVERY OF BIOACTIVE AGENTS
专利权人:
AGENCY FOR SCIENCE; TECHNOLOGY AND RESEARCH
发明人:
KURISAWA, MOTOICHI,NG, SHENGYONG,CHUNG, JOO EUN
申请号:
EP10808429
公开号:
EP2464388A4
申请日:
2010.08.11
申请国别(地区):
EP
年份:
2013
代理人:
摘要:
There is presently provided a suspension of immiscible particles in a solution, wherein the particles comprise an agglomeration of a bioactive agent, for example an anti-cancer agent and a plurality of conjugates of a hyaluronic acid and a flavonoid, for example a catechin-based flavonoid, wherein the particles are on average from about 15 nm to about 300 nm in diameter and wherein the bioactive agent is releasably retained in the particles by the flavonoid. The suspension is useful for the delivery of the bioactive agent to cells, including cancer cells. There are also provided a therapeutic formulation comprising the suspension, as well as methods for using the suspension and therapeutic formulation, including for delivery of a bioactive agent to a cell and for treating a disease, including cancer.
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中国工程科技知识中心
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