The purpose is to provide a tacrolimus-containing pharmaceutical composition which is a creamy preparation for external application having good feeling upon use and has high stability of the main ingredient contained therein (a high main ingredient residual ratio), and of which the concentration in the skin can be controlled readily. Specifically disclosed is an oil-in-water type creamy composition which is characterized by comprising (A) tacrolimus, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof, (B) an oil prepared by mixing (a) a medium-chain fatty acid triglyceride with (b) salicylic acid ethylene glycol and/or diisopropyl sebacate, (C) an emulsifying agent having an HLB value of 12 or more, and (D) a hydrophilic polymer, and is also characterized by having a pH value of 4-7.
