HUANG, ARTHUR J,KELLEY, ROBERT F,LOWMAN, HENRY,VAN LOOKEREN CAMPAGNE, MENNO,WINTER, CHARLES M
申请号：
NZ58845709
公开号：
NZ588457A
申请日:
2009.04.27
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed is an anti-Factor D antibody or an antibody functional fragment thereof. The disclosed antibody comprises a light chain variable domain and a heavy chain variable domain, wherein the light chain variable domain comprises light chain hypervariable region (HVR)-1 comprising ITSTDIDDDMN (SEQ ID NO: 30), light chain HVR-2 comprising GGNTLRP (SEQ ID NO: 35), and light chain HVR-3 comprising LQSDSLPYT (SEQ ID NO: 38), wherein the heavy chain variable domain comprises heavy chain HVR-1 comprising GYTFTNYGMN (SEQ ID NO: 39), heavy chain HVR-2 comprising WINTYTGETTYADDFKG (SEQ ID NO: 40), and heavy chain HVR-3 comprising EGGVNN (SEQ ID NO: 41), wherein the anti-Factor D antibody or antibody fragment thereof further comprises one or more of the following substitutions (a) to (e): (a) substitution of the amino acid at position 10 of SEQ ID NO: 30 with L or I (b) substitution of the amino acid at position 11 of SEQ ID NO: 30 with A or Q (c) substitution of the amino acid at position 3 of SEQ ID NO: 35 with S or A (d) substitution of the amino acid at position 5 of SEQ ID NO: 41 with A or Q or (e) substitution of the amino acid at position 6 of SEQ ID NO: 41 with A or Q, and/or the heavy chain variable domain comprises an E at position 1.
