Disclose for it is characterized in that the deposition of amyloid the new method resisted the disease. Method usually relies on immunization against amyloid protien (APP) or beta amyloid (A2). Immunization preferably by self APP or A2 analog management, can against self amyloid polypeptide cause antibody generate the analog influence. Especially preferred, because an immunogene is self A2, with primary by introducing single or several foreign countries, the T cell antigen that the sum of immundominance mixes determines position. Also disclose the nucleic acid vaccination to APP or A2 and inoculation using the live vaccine and method and apparatus that can be used for being inoculated with. Such method and apparatus include that method is used to prepare analog and pharmaceutical preparation and nucleic acid fragment, vector, changes cell, polypeptide and pharmaceutical preparation
