Ashkenazi, Avi J.,Hymowitz, Sarah,Kelley, Robert F.,Koumenis, Iphigenia,Leung, Susan,O'Connell, Mark,Pai, Roger,Shahrokh, Zahra,Simmons, Laura,OConnell, Mark
申请号：
AU2011265480
公开号：
AU2011265480A1
申请日:
2011.12.22
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2011265480A120120119.pdf#####ABSTRACT Methods of making Apo-2 ligand and formulations of Apo-2 ligand using divalent metal ions are provided. Such divalent metal ions include zinc and cobalt which improve Apo-2 ligand trimer formation and stability. The crystal structure of Apo-2 ligand is also provided, along with Apo-2 ligand variant polypeptides identified using oligonucleotide-directed mutagenesis.
