FLYNN, DANIEL L.,PETILLO, PETER A.,KAUFMAN, MICHAEL D.
申请号：
CA2742007
公开号：
CA2742007C
申请日:
2009.10.29
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
Compounds of the present invention find utility in the treatment of mammaliancancers and especially human cancersincluding, but not limited to, malignant melanomas, solid tumors,glioblastomas, ovarian cancer, pancreatic cancer, prostatecancer, lung cancers, breast cancers, kidney cancers, hepatic cancers,cervical carcinomas, metastasis of primary tumor sites,myeloproliferative diseases, chronic myelogenous leukemia, leukemias,papillary thyroid carcinoma, non-small cell lung cancer,mesothelioma, hypereosinophilic syndrome, gastrointestinal stromal tumors,colonic cancers, ocular diseases characterized byhyperproliferation leading to blindness including various retinopathies,diabetic retinopathy, rheumatoid arthritis, asthma, chronicobstructive pulmonary disease, mastocytosis, mast cell leukemia, and diseasescaused by PDGFR-.alpha. kinase, PDGFR-.beta. kinase, c-KITkinase, cFMS kinase, c-MET kinase, and oncogenic forms, aberrant fusionproteins and polymorphs of any of the foregoingkinases.
