FORMULATIONS FOR DERMAL DELIVERY OF POLYMER CONJUGATES OF INDOLOCARBAZOLE COMPOUNDS WITH REDUCED EXPOSURE

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专利权人:

Sienna Biopharmaceuticals; Inc.

发明人:

Valentina Mainero,Silvio Traversa

申请号：

US16208278

公开号：

US20190209472A1

申请日:

2018.12.03

申请国别(地区):

US

年份:

2019

代理人:

摘要：

Topical formulations to treat skin conditions, such as psoriasis, are provided in which a polymer conjugate of an indolocarbazole exhibits reduced systemic exposure. An example formulation includes the TrkA antagonist, SNA-120, together with a preservative/antioxidant, a preservative/solvent, a solvent, a solvent/moisturizing agent, a stiffening agent, and one or more emollients/emulsifying agents.

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