ЛИ Квангхо (US),НЮ Децян (US),ПЕТТЕР Расселл С. (US),БАЕВСКИ Мэтью Фрэнк (US),СИНГХ Джасвиндер (US)
申请号：
RU2013118648/04
公开号：
RU2013118648A
申请日:
2011.10.31
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: n is 0, 1 or 2 m is 0, 1 or 2, wherein m and n are not simultaneously 0 W represents -O- or -NH- R is -OR each R independently represents an alkyl or Cftoralkil R is -CF, Cl or Br G represents -O-, -NR-, -S (O) - or -CH (oR) - R is -C (O) -R, -C (O) oR, -C (O) NHR, -SO-R, -SONH, -C (O) OH or--Calkilen -SO-alkylene-OH R is hydrogen , alkyl or Cftoralkil, iRpredstavlyaet hydrogen or -C (O) OR.2. A compound of formula I-a: or a pharmaceutically acceptable salt thereof, wherein: n is, for 0, 1 or 2 m is 0, 1 or 2, wherein m and n are not simultaneously 0 W represents -O- or -NH- R is -OR each R independently represents Ci ^ alkyl or Cftoralkil R is -CF, Cl or Br G represents -O-, -NR- or -CH (oR) - R is -C (O) - R, -C (O) oR, -C (O) NHR, -SO-R, -SONH, -C (O) OH or--Calkilen -SO-alkylene-OH, iRpredstavlyaet hydrogen, Ci ^ alkyl or Cftoralkil.3 . A compound according to claim 1 or 2, characterized in that W represents a -NH-.4. A compound according to claim 3, characterized in that R is -CF.5. A compound according to claim 1 or 2, characterized in that said compound is a compound of formula II: or a pharmaceutically acceptable sol.6. A compound according to claim 5, characterized in that W represents a -NH-.7. A compound according to claim 6, characterized in that R is -CF.8. A compound according to claim 5, characterized in that it satisfies at least one of conditions (a) and (b) :( a) W represents -O- or -NH-, and (b) R is -CFili Cl. 9. A compound according to claim 8, characterized in that: (a) W represents -O- or -NH-, and (b) R is -CFili Cl.10. A compound according to claim 5
