The present invention relates to methods and devices for treating wet AMD, CNV, wet AMD associated with CNV and/or wet AMD associated with RVO in a human subject in need thereof. In certain aspects, devices provided herein include a medicament container defining a lumen configured to contain a medicament, a distal end portion of the medicament container including a coupling portion configured to be removably coupled to a needle assembly, a proximal end portion of the medicament container including a flange and a longitudinal shoulder； a piston assembly including a distal end portion movably disposed within the lumen of the medicament container； and a handle coupled to a proximal end portion of the piston assembly.
