Anabelle Freund;Arin Ghasparian;Kerstin Möhle;John A. Robinson;Francesca Boato;Richard M. Thomas
发明人:
Francesca Boato,Anabelle Freund,Arin Ghasparian,Kerstin Möhle,John A. Robinson,Richard M. Thomas
申请号：
US12518269
公开号：
US08450284B2
申请日:
2007.12.06
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The invention relates to lipopeptide building blocks consisting of a peptide chain comprising a coiled-coil domain, linked covalently to a lipid moiety comprising long alkyl or alkenyl chains, and optionally linked to an antigen； and to helical lipopeptide bundles and synthetic virus-like particles formed by aggregation. The nanometer size and shape of these bundles and particles, their stability under aqueous physiological conditions, their chemical composition, the possibility to incorporate B- and T-cell epitopes, and their production by chemical synthesis, make them highly suitable as vaccine delivery vehicles.
