The invention relates to an oral extended release solid pharmaceutical composition of donepezil hydrochloride comprising at least one pH independent polymeric release retardant and one more pharmaceutically acceptable excipient. The invention also describes a process for preparation of donepezil hydrochloride extended release tablet formulation which is suitable for scale up and commercial level manufacturing. Donepezil extended release formulation of the present invention exhibits extended drug release profile over the period of 12 hours.
