DE STAAT DER NEDERLANDEN; VERTEGENWOORDIGD DOOR DE MINISTER VAN VOLKSGEZONDHEID; WELZIJN EN SPORT
发明人:
申请号：
PT04808827
公开号：
PT1699919T
申请日:
2004.12.24
申请国别(地区):
PT
年份:
2017
代理人:
摘要：
The present invention relates to pneumoviral virions comprising a viral genome that has a mutation in a gene coding for a protein that is essential for infectivity of the pneumovirus, whereby the mutation causes a virus produced from only the viral genome to lack infectivity, and whereby the virion comprises the protein in a form and in an amount that is required for infectivity of the virion. The invention for relates to methods for producing the pneumoviral virions and for using the virions in the treatment or prevention of pneumoviral infection and disease. A preferred pneumoviral virion is a virion of Respiratory Syncytial Virus in which preferably the gene for the G attachment protein is inactivated and complemented in trans.
