PEPTIDE； NUCLEIC ACID OR VECTOR OF EXPRESSION； HOSPEDEIRA CELL； IN VITRO METHOD FOR PRODUCING ACTIVATED CYTOTOXIC T-LYMPHOCYTE； SUCH LYMPHOCYTES； AND USES
Peptideo； nucleic acid or expressed vector； host cell； in vitro method for producing activated cytotoxic lymphocytes； such lymphocytes； and uses of this invention refer t o immunotherapeutic peptides and their use in immunotherapy, in particular cancer immunotherapy. More particularly, it refers t o a peptid comprising the SEQ ID sequence no.8 (spqyswringipqht) which induces T cells of cross reaction with said peptideo, such peptid or variant having a t o tal length of 16 t o 100aminoethides. Peptidic epitopos of auxiliary caelujah associated with tumor, alone or in combination with other peptides associated with tumours, are disseminated here,Which serve as active pharmaceutical ingredients in compositions of vaccines stimutizing immune antitumor responses. In particular, the composition of peptides in this invention can be used in vaccine compounds to extract immune antitumoral responses against colorectal cancer.peptideo； acido nucleico ou vetor de expressao； celula hospedeira； metodo in vitro para produ- zir linfocitos t citotoxicos ativados； tais linfocitos； e usos a presente invencéo refere-se a peptideos imunoterapicos e seu uso em imunoterapia, em particular na imunoterapia do cancer. mais particularmente ainda refere-se ela a um peptideo compreendendo a sequéncia seq id no.8 (spqyswringipqqht) que induz células t de reacéo cruzada com o dito peptideo, tal peptideo ou variante tendo um comprimento total de entre 16 e 100 aminoécidos. divulgam-se aqui epitopos peptidicos de céluia t auxiliar associados a tumor, isoladamente ou em combinagéo com outros peptideos associados a tumores, que servem como ingredientes farmacéuticos ativos em composicoes de vacinas estimuiadoras das respostas imunes antitumor. em particular, a composicéo dos peptideos da presente invencao pode ser usada em composicoes de vacina para extrair respostas antitumorais imunes contra céncer colorretal.
