HETEROATOM CONTAINING DEOXYURIDINE TRIPHOSPHATASE INHIBITORS

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专利权人:

UNIVERSITY OF SOUTHERN CALIFORNIA

发明人:

LADNER, ROBERT D.,GIETHLEN, BRUNO

申请号：

CA2935717

公开号：

CA2935717A1

申请日:

2015.01.02

申请国别(地区):

CA

年份:

2015

代理人:

摘要：

Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions in a method of treating cancer. The dUTPase inhibitors disclosed contain a uracil isostere in the molecule represented by a 2,6-diketopiperazine moiety. Thioanalogs of the uracil isostere where a thione replaces each of the ketone are also disclosed.

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