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TREATMENT OF ERECTILE DYSFUNCTION AND OTHER INDICATIONS
专利权人:
Strategic Science & Technologies; LLC
发明人:
Eric T. Fossel
申请号:
US14067308
公开号:
US20140051707A1
申请日:
2013.10.30
申请国别(地区):
US
年份:
2014
代理人:
摘要:
The present invention generally relates to the transdermal delivery of various compounds. In some aspects, transdermal delivery may be facilitated by the use of a hostile biophysical environment. One set of embodiments provides a composition for topical delivery comprising a phosphodiesterase type 5 inhibitor and/or a salt thereof, and optionally, a hostile biophysical environment and/or a nitric oxide donor. In some cases, the composition may be stabilized using a combination of a stabilization polymer (such as xanthan gum, KELTROL® BT and/or KELTROL® RD), propylene glycol, and a polysorbate surfactant such as Polysorbate 20, which combination unexpectedly provides temperature stability to the composition, e.g., at elevated temperatures such as at least 40° C. (at least about 104° F.), as compared to compositions lacking one or more of these.
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中国工程科技知识中心
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