Various methods employing transvascular access devices are described, including a method of placing a central catheter in a peripheral vein in an arm of a patient； a method of providing percutaneous access to the heart of a patient； a method of clearing a clotted arteriovenous dialysis graft； a method of creating multiple access points into a single blood vessel； a method of creating an AV fistula in a patient； and a method of providing a bypass to a blockage in a popliteal artery in a patient.
