GENETICALLY MODIFIED GENES AND CELLS, AND METHODS OF USING SAME FOR SILENCING VIRUS GENE EXPRESSION

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专利权人:

Wisconsin Alumni Research Foundation

发明人:

Nathan Mark SHERER,Ryan Thomas BEHRENS

申请号：

US16561847

公开号：

US20200071671A1

申请日:

2019.09.05

申请国别(地区):

US

年份:

2020

代理人:

摘要：

Genetically modified CCNT1 and XPO1 genes encoding proteins that inhibit virus infection in cells. The genetically modified CCNT1 gene encodes a protein with a C261Y substitution with respect to the human CCNT1 protein. The genetically modified XPO1 gene encodes a protein with P411T, M412V, and/or F414S substitutions with respect to the human XPO1 protein. The genetically modified CCNT1 and XPO1 genes can be introduced in cells. The cells comprising the genetically modified CCNT1 and XPO1 genes can be introduced in a subject with a virus infection to treat the infection.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/