The present invention provides methods for protecting a virus contained in a bioprocess bag from surface-induced degradation, thereby improving the compatibility of viruses with these plastics by preserving quantity and potency of the contained viruses during storage in bioprocess bags over a period of time. It was shown herein that viruses can quickly degrade when stored in bioprocess bags and that the addition of a β-cyclodextrin to a virus-containing solution stored in a bioprocess bag unexpectedly prevents the plastic surface-induced degradation of said virus.
