Hynd, George,Finch, Harry,Cramp, Michael Colin,Arienzo, Rosa,Crackett, Peter,Griffon, Yann,Harrison, Trevor Keith,Montana, John Gary,Ray, Nicholas Charles
申请号：
NO20081327
公开号：
NO343189B1
申请日:
2008.03.13
申请国别(地区):
NO
年份:
2018
代理人:
摘要：
The therapeutical uses of quinoline and they. Compound [1] CRTH2 antagonists of formula are useful treatment conditions, with inflammatory components, wherein: 1 ^ ^ ^ of R ^, R 2,3 R ^ ^ ^ ^ of R, ^ ^ 4 and R 5 are independent hydrogen, 1~C of C 6 of alkyl~~~, 1~C of fluoroalquila C 6~~~, ciclopropila, dizzy, S(N) R ^ 6~~~, so when~7 27 8-^ ^ ^ ^R ^ n, R ^ ^ ^ 78, the R of rubber (C) ^ ^ ^ 6,2~7(C of R-CO) 78 zero zero meters of (R, C) ^-^ 6 of ^ ^ ^ ^ R. 2~~or one group) or 9 square centimeters； Wherein each R is independent alkyl, 1~C of 6(C 6 ~ ~ ~ ~ ~, fluoroalquila C 1~C, 6~cicloalquila, aryl, R ^ ^ or heteroarila； 7,8 be C~1 independent alkyl groups R ^ ^~C~6~cicloalquila, aryl or heteroarila； R is that R ^ ^ 7,8 are independent alkyl groups, 1~C of C 6~~~, 1~C of fluoroalquila C 6~~~, cicloalquila, cicloalquila(C 1~C alkyl, aryl, 6~~) heteroarila or hydrogen； R is alkyl hydrogen 9,1~C of C 6 ~ ~ ~ ~ ~, 1~C of fluoroalqula C 6~, cicloalquila cicloalquila(alkyl, 1~C of C 6 ~ ~ ~ ~) or one group of R-2~6 meter, it is Chr(10 ^(-,) C, S~N(, -) or nearly 10 ^-^, wherein N is an integer and R ^ 2 0-10) it is hydrogen. The C1-3 or C of alkyl~~~~~(1~3 DEG C of fluoroalquila C groups； B is that one or one radical selection has the 2 ^-^ of divalente CH CH between directly contacting, 2 CH of ^ ^ ^ ^, 2 ^ ^, CHR 11,11,12 CH 2 of the ^-^ of chromium R~, 11 CHR CHR of~~^ ^, the R ^ ^ of CH 2~^ ^ ^ ^ 12 11, the CHR CHR ^ ^ 11 12 and radical formula of divalent (R is 11 12 chromium ^ ^) p ~-Z. Wherein Z is attached in 3 ^ ^ ^ of R ^ 1 ^ ^ ^ 2, R and R ^ wherein； 11, wherein R be the C1-3 of alkyl C~~~, ciclopropila, 1~C of fluoroalquila C 6~~~^ ^； R is methyl or fluorometila 12, either 1 or 2； Z is-,-NH or S(n)), it is 0-2 that wherein n, which is an integer,； X is a kind of sour 3-hydroxycarboxylic acid, tetrazolium, isoxazole, hydroxamic acid, phosphonic acids or one or a set of formula (=0) (2 nhso of R ^~~^ 2~6 or SO 4 ~ (NHC=0) (the R ^ 6 with sulfonic acid of fosfona
