Antler pet chew products and methods of manufacturing such products are disclosed. Some antler pet chew products may comprise an antler section length defined by a distance between proximal and distal ends and antler section sides extending between the proximal and distal ends. At least one antler section side may comprise a natural antler exterior, while one or more other antler section sides may comprise an exposed antler interior. A layer of dried, hardened bonding substance, such as a cheese formulated to bond with antler, may be bonded to the antler section sides comprising the exposed antler interior. One or more cavities may be drilled in the antler section and the dried, hardened bonding substance may be bonded to cavity sidewalls.