MCLELLAN, ALEXANDER,SUN, SHENGGUO,WEAVER, DONALD, F.,REED, MARK, ANDREW
申请号：
HK14111776.1
公开号：
HK1198161A
申请日:
2014.11.21
申请国别(地区):
HK
年份:
2015
代理人:
摘要：
The present application provides terpene analogues of Formula 1 and methods and uses thereof for treating neurological conditions such as pain in general and neuropathic pain specifically. wherein: Y is a C1 to C20 alkylene, C&boxHO, SO, SO2, or absent X is H, OR1, N&mdash(R2)2, a C1 to C20 alkyl, or a heterocyclyl (for example, heteroaryl), wherein when Y is absent X is not H R1 is H, a C1 to C20 alkyl, or a CH2-aryl R2 is independently H, a C1 to C20 alkyl, aryl, OR1, CN or C(&boxHO)&mdashR3 R3 is a substituted or unsubstituted C1 to C20 alkyl, or a aryl W is H, C1 to C20 alkyl, or aryl and Z is C1 to C20 alkylene or a pharmaceutically acceptable isomer, salt or ester thereof. These terpene analogues are useful in treating pain and can also be used to treat other electrical disorders in the central and peripheral nervous system.
