Kamal Surendrakumar Mehta,Saurabh Srivastava,Dinesh Kumar,Amit Kumar Jha,Subash Chandra Mohanta,Sunil Kumar Panda,Ganesh Vinayak Gat
申请号：
US16714346
公开号：
US20200253946A1
申请日:
2019.12.13
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention discloses stable delayed release multiparticulate powder for oral suspension of proton pump inhibitor compounds comprising: a) a core with an effective amount of proton pump inhibitor and at least one or more pharmaceutical excipients, b) at least one water-soluble seal coating over core c) at least one enteric coating layer over the seal coat wherein the core is free of a surfactant. The prior art discloses restrictive formulation techniques and suggests higher amounts of various excipients to achieve desired technical attributes. The prepared test formulations exhibited desired pharmaceutical technical attributes like drug release, assay, stability, no polymorphic change, reduced sticking to nasogastric and gastronomy tubes, and packaging material.
