RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL
发明人:
LEE, DEAN ANTHONY,FOLTZ-STRINGFELLOW, JENNIFER ANN,EDWARDS-MOSEMAN, JENA
申请号：
CA3090096
公开号：
CA3090096A1
申请日:
2019.01.29
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
An NK cell with low SMAD3 expression and altered gene expression profile resulting in high cytokine expression and TGF-ß superfamily resistance is described, refered to herein as TGF-ß superfamily-imprinted Natural Killer Cells (TGFßi NK cells). A method of treating cancer or infection in a subject in need thereof is described. The method includes administering a therapeutically effective number of TGFßi NK cells to the subject. A method of producing TGFßi NK cells is described by in vitro activation of natural killer cells in the presence of a TGF-ß superfamily cytokine.
