Massachusetts Institute of Technology;Trustees of Boston University
发明人:
Ning Mao,Douglas Ewen Cameron,James Collins
申请号：
US15580845
公开号：
US10802021B2
申请日:
2016.06.09
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Provided herein are microorganisms engineered with hybrid receptors and genetic circuits. Also provided are hybrid receptors having a CqsS polypeptide and a heterologous histidine kinase domain of a two-component system. Methods for using engineered microorganisms to sense and destroy pathogens (e.g., Vibrio cholerae) are also provided.
