#$%^&*AU2018205093A120180726.pdf#####ABSTRACT A method for formulating a topical composition containing one or more Pro-Resolution Pathway Stimulators by: (a) selecting an active ingredient； (b) quantifying the inhibition in release of one or more Inflammatory Metabolites or Inflammatory Metabolite Markers from cells to which the 5 active is exposed, or (c) quantifying the increase in release of one or more Pro-Resolving Lipid Mediators or Pro-Resolving Lipid Mediator Markers in cells to which the active is exposed, (d) selecting the active that shows: (i) a decrease in cellular concentration of Inflammatory Metabolites or Inflammatory Metabolite Markers individually or in combination； and/or (ii) an increase in cellular concentration of Pro-Resolving Lipid Mediators or Pro-Resolving Lipid 0 Mediator Markers individually or in combination (e) formulating the active selected in (d) into a topical cosmetic product.
