FIELD: medicine.SUBSTANCE: invention relates to medicine, namely anesthesiology and resuscitation, and can be used to predict the lethal outcome in patients with multiple organ dysfunction. This method involves determining the level of procalcitonin, C-reactive protein, total cholesterol in the blood. In the method, the risk of fatal outcome (P) is calculated by the formula P=PC+CRP+TC, where PC is the procalcitonin concentration in the blood of patients, <0.8 ng/ml – 0 points, from ≥0.8 ng/ml to <2.0 ng/ml – 1 point, from ≥2.0 ng/ml to <10.0 ng/ml – 2 points, ≥10.0 ng/ml – 3 points; CRP is the C-reactive protein concentration in the blood of patients, <90 mg/l – 0 points, from ≥90 mg/l to <200 mg/l – 1 point, from ≥200 mg/l to <300 mg/l – 2 points, ≥300 mg/l – 3 points; TC is the concentration of total cholesterol in the blood of patients, >3.7 mmol/l – 0 points, from ≤3.7 mmol/l to >2.6 mmol/l – 1 point, from ≤2.6 mmol/l to >1.8 mmol/l – 2 points, ≤1.8 mmol/l –