COMPOSITIONS CONTENANT DES PRODUITS BIOPHARMACEUTIQUES INACTIVES MAIS THERAPEUTIQUEMENT ACTIFS, STABLES A TEMPERATURE AMBIANTE ET PROCEDES DE FORMULATION ASSOCIES
The disclosure concerns compositions containing inactivated but therapeutically active biopharmaceuticals, and methods for formulation thereof. Biopharmaceuticals are encapsulated and immobilized in dry amorphous carbohydrate-glass and irradiated for inactivation while in the dry state. The resulting compositions provide ambient-temperature stable, therapeutically active but inactivated biopharmaceuticals for use in vaccines and other applications.
