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Glucopiranosyl derivatives and their uses in medicine
专利权人:
Sunshine Lake Pharma Co.; Ltd.
发明人:
WEI, Yonggang,WEN, Jiaping,ZHU, Guozhi,LU, Yonghua,WANG, Heran,WANG, Yincai,YUAN, Mingyun,GU, Zheng,WU, Wuyong,KANG, Panpan,ZHANG, Zongyuan,CHEN, Gang,TANG, Pengcho
申请号:
ES14847239
公开号:
ES2605886T3
申请日:
2014.09.26
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound having the Formula (I) or a stereoisomer, a geometric isomer, a tautomer, a racemate, an N-oxide, a hydrate, a solvate or a pharmaceutically acceptable salt thereof, ** Formula ** in which each one of R1, R2 and R3 is -OH; where R6 is -OR6a or -OC (>; = O) R6b; and R4 is independently -H, alkyl, alkylamino, alkynyl, alkenyl or cyano, and where optionally each of alkyl, alkylamino, alkynyl and alkenyl is substituted with one or more substituents independently selected from -F, -Cl, -Br, -I, hydroxy, cyano, amino, alkynyl, alkenyl, carboxy, mercapto, alkylamino and trifluoromethyl; and R5 is independently alkyl, alkylamino, alkynyl, alkenyl or cyano, and wherein optionally each of alkyl, alkylamino, alkynyl and alkenyl is substituted with one or more substituents independently selected from -F, -Cl, -Br, -I, hydroxy, cyano, amino, alkynyl, alkenyl, carboxy, mercapto, alkylamino and trifluoromethyl; or R4 and R5, together with the carbon atom to which they are attached, form a ring A, where ring A is a saturated or unsaturated 3 to 8 member ring, and where ring A optionally contains one or more atoms or atomic groups independently selected from -NH-, -O-, -S-, -C (>; = O) - and -S (>; = O) -, and where ring A is optionally substituted with one or more substituents independently selected from -F, -Cl, -Br and -I; or in which R4 is -H; and R5 and R6, together with the carbon atom to which they are attached, form a ring B, where ring B is a 3 to 8 member ring, saturated or unsaturated, and where ring B optionally contains one or more atoms or atomic groups independently selected from -NH-, -O-, -S-, -C (>; = O) - and -S (>; = O) -, and where ring B is optionally substituted with one or more substituents independently selected from -F, -Cl, -Br and -I; wherein R 6a is -H, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl, and wherein optionally each of alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, arylalkyl and hetero
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