Described herein is a refrigeration system for bedbug eradication. The refrigeration system comprises a generator, a condensing unit, and a portable evaporating and blowing unit connected with the condensing unit for transporting into a bedbug-infested room of a building. Temperature sensors are used for monitoring an ambient temperature in the bedbug-infested room to ensure that the temperature drops to a predetermined temperature to kill the bedbugs and their eggs. Moisture in the bedbug-infested room is removed with a dehumidifier prior to cooling down the bedbug-infested room with the evaporating and blowing unit.